teratogenesis test

In order to furnish scientific evidence for using HEGF safely, the toxity test on sensi-tive period of teratogenesis in rat and sperm teratogenicity test on mouse were carried out.

我们为新药人体表皮生长因子（以下简称HEGF）提供安全使用的科学依据，进行了大鼠致畸敏感期毒性试验和小鼠精子畸形试验。

The results indicated that no adverse effect were observed on the body weight gain and fecundity of pregnant rats and fetuses growth ( appearance, viscera and bone), the transgenic rice expressing double antisense branching enzymes gene have no teratogenesis on test rats. 4.

结果表明，转基因大米对孕鼠体重增长、孕鼠生殖能力、胎鼠发育（外观、内脏及骨骼）均未产生不良影响，即转双反义分支酶基因大米未对试验大鼠产生致畸作用。

Teratogenesis Test of Momordica Charantia Extract in Mice

苦瓜提取物对小白鼠致畸试验

The results showed that in this kind of experiment condition, the acute and chronic toxicity reaction, inducton of teratogenesis and mutagenesis on the test animal were not obvious.

结果显示，在本实验余件下，对受试动物不产生明显急慢性毒性反应，亦未见诱发致畸、致突变作用。

The drinking water of photochemical disinfectant had no effect on gene mutation in Ames test, and didn ′ t make increase micronucleus formation of mice bone marrow and sperm deformity in the teratogenesis test of mice.

Ames试验结果是光化学消毒的饮用水无菌株基因突变作用，Ames试验结果阴性。在小鼠骨髓PCE微核试验中，光化学消毒水对小鼠无致骨髓PCE微核发生率升高的作用。